Ribosomal protein S18



Ribosomal protein S18 (RPS18) is one of the 22 proteins which belong to the small subunit of the bacterial ribosome. It is involved in binding the aminoacyl-tRNA complex at the A-site. The images at the left and at the right correspond to one representative RPS18, i.e. the crystal structure of Ribosomal protein S18 from Thermus thermophilus (2zm6, chain R).

3D Structures of Ribosomal protein S18
Update June 2011

S18
2cns, 2cnt – StRPS18 N-alpha-acetyltransferase modification+acetyl CoA – Salmonella typhimurium

2cnm - StRPS18 N-alpha-acetyltransferase modification+ polypeptide inhibitor

S18 in small ribosomal subunit
2zm6, 1n36, 1j5e, 3oge, 3ogy, 3ohc, 3ohd, 3ohy, 3oi0, 3oi2, 3oi4, 3oto - TtRPS18 in 30S ribosomal subunit+THX+16S RRNA - Thermus thermophilus

2vqe, 2vqf, 2uuc, 2e5l, 2uu9, 2uua, 2uub, 3pyn, 3pyq, 3pys, 3pyu - TtRPS17 in 30S ribosomal subunit+16S RRNA+RNA fragment

3kc4 – EcRPS18 in 30S ribosomal subunit – Escherichia coli

3i1m, 3i1o, 3df1, 3df3, 2vho, 2vhp, 2avy, 2aw7, 1pnx, 3ofa, 3ofb, 3ofx, 3ofy, 3ofo, 3ofp, 3or9, 3ora, 3oaq, 3oar - EcRPS18 in 30S ribosomal subunit+16S RRNA

1i94, 1fka - TtRPS18 in 30S ribosomal subunit+16S RRNA

1p87, 1p6g - EcRPS18 in 30S ribosomal subunit+16S RRNA – Cryo-EM

3bbn - RPS18 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach

S18 in small + large ribosomal subunit
1ml5 - EcRPS18 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM

S18 in small ribosomal subunit+ chain release factor
3mr8, 3ms0 – TtRPS18 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA

3d5a, 3d5c - TtRPS18 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA

2b64 - TtRPS18 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1

2b9m - TtRPS18 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2

2x9r, 2x9t, 2wh1, 2wh3 - TtRPS18 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA

3f1e, 3f1g - TtRPS18 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA

S18 in small ribosomal subunit+tRNA+mRNA
2hgi - TtRPS18 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet

2hgp - TtRPS18 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA

2i2p, 2i2u - EcRPS18 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA

2hgr - TtRPS18 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA

1yl4 – TtRPS18 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator

1pns – EcRPS18 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA

1xnq, 1xnr - TtRPS18 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA

S18 in small ribosomal subunit+A-site tRNA
2uxd, 2uxc - TtRPS18 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA

1n32, 1n33 - TtRPS18 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA

1n34 - TtRPS18 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA

1xmo, 1xmq - TtRPS18 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA

2uxb - TtRPS18 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA

S18 in small ribosomal subunit+P-site tRNA
3i8g - TtRPS18 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA

3i8h, 3i9b, 3i9d - TtRPS18 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA

1ibk - TtRPS18 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA

2wwl - EcRPS18 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - Escherichia coli

3i1q - EcRPS18 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA

3i1s, 3i1z, 3i21 - EcRPS18 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA

S18 in small ribosomal subunit+A-site tRNA+P-site tRNA
1ibl, 1ibm - TtRPS18 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA

S18 in small ribosomal subunit+P-site tRNA+E-site tRNA
2ow8 - TtRPS18 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA

2b9o - TtRPS18 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA

2qnh - TtRPS18 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA

S18 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA
2gy9, 2gyb - EcRPS18 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM

1jgo, 1jgp, 1jgq, 1gix - TtRPS18 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA

3e1a, 3e1c - EcRPS18 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA

S18 in small ribosomal subunit + antibiotics
1i95, 1i97, 2hhh, 2f4v - TtRPS18 in 30S ribosomal subunit+16S RRNA+antibiotic

1hnx, 1hnw, 1hnz, 1fjg – TtRPS18 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic

2qbb, 2qb9, 1vs5, 1vs7, 2qan, 2qal, 2qou, 2qow, 2qoy, 2qp0, 2z4k, 2z4m  - EcRPS18 in 30S ribosomal subunit+16S RRNA+antibiotic

2j00, 2j02 - TtRPS18 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA

2wdg, 2wdh, 2wdk, 2wdm - TtRPS18 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe+paromomycin

3knj, 3knh - TtRPS18 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin

3knl, 3knn - TtRPS18 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin

S18 in small ribosomal subunit + ribosome recycling factor
2qbd, 2qbf – EcRPS18 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor

3r8n, 3r8o – EcRPS18 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA

2qbh, 2qbj - EcRPS18 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin

2v46, 2v48 - TtRPS18 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet

S18 in small ribosomal subunit + elongation factor
2wri, 2wrk, 2xsy, 2xuy - TtRPS18 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G

2wrn, 2wrq - TtRPS18 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4

3fic - TtRPS18 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A

3izv – EcRPS18 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU

3izw – EcRPS18 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU

2y0u, 2y0w, 2y0y, 2y12, 2y10, 2y18, 2y14, 2y16 – TtRPS18 in 30S ribosomal subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU

2xqd – TtRPS18 in 30S ribosomal subunit+THX+E-site tRNA+mRNA +16S RRNA+elongation factor TU-B

3fih - EcRPS18 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU

3huw, 3huy - TtRPS18 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P

1s1h - yRPS18 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast

S18 in small ribosomal subunit + translation initiation factor
1i96 - TtRPS18 in 30S ribosomal subunit+THX+IF3+16S RRNA

1hr0 - TtRPS18 in 30S ribosomal subunit+THX+IF+16S RRNA

S18 in small ribosomal subunit + various proteins
3kiq, 3kis, 3kiu, 3kix - TtRPS18 in 30S ribosomal subunit+toxin RelE+16S RRNA

1voq, 1vos, 1vov, 1vox, 1voz - EcRPS18 in 30S ribosomal subunit+protein Y+16S RRNA

2xfz, 2xg1 - TtRPS18 in 30S ribosomal subunit+tRNA Phe+mRNA+colicin E3+16S RRNA

1x18 – TtRPS18+TtRPS2+TtRPS7+TtRPS11+ERA GTPase+16S RRNA fragment

3j00 – EcRPS18 + 16S RRNA + FTSQ + apolipoprotein A-I

S18 in small 40S ribosomal subunit + various proteins
3jyv - RPS18 in 40S ribosomal subunit+tRNA Phe+RACK1 +18S RRNA – Thermomyces lanuginosus

2zkq – RPS18 in 40S ribosomal subunit+RNA fragments+RACK1+18S RRNA

3iz6 – RPS18 in 40S ribosomal subunit+RACK1 – wheat – Cryo EM

3o2z, 3o30 – yRPS18 in 40S ribosomal subunit+18S RRNA+RACK1

S18 in part of small ribosomal subunit
3iy8 – EcRPS18+EcRPS5+EcRPS6+EcRPS8+EcRPS9+ EcRPS11+EcRPS12+EcRPS15+EcRPS16+EcRPS17+Leishmania taretolae mRNA

1g1x - TtRPS18+TtRPS6+TtRPS15+16S RRNA fragment